My laboratory utilizes computational and experimental methodologies to provide understanding of the immune system, host-pathogen interaction and evolution from humans to arthropod vectors of human disease. My areas of focus are 1) Dynamics of the lymphocyte repertoire in humans and mice in response to various pathogenic insults, such as acute viral diseases and vaccination; 2) Comparative transcriptome analysis for the characterization of biological pathways related to vectorial competence in mosquitoes and Reduvidae; 3) Comparative immunology focused on the evolution of acquired antigen receptors; 4) Seroprevalence studies for public health surveillance. We use standard microbiology, molecular biology and immunology tools, as well as NGS and computational biology tools to generate integrative data to leverage our understanding of the immune response and host-pathogen co-evolution that may lead to improved strategies for vector-borne diseases control and vaccination.