Rob Miller, PhD


Photo: Rob Miller

CETI Director, Professor

Department of Biology, University of New Mexico


Research Interests:

Evolution of vertebrate immune systems.

B.S. Microbiology, Pennsylvania State University
Ph.D. Medical Microbiology, Thomas Jefferson University

Current projects
Evolution of novel T cell receptors, evolution of non-classical MHC genes, evolution of strategies for transmission of maternal immunity.

People in the Lab

Graduate Students
Bethany Fehrenkamp
Victoria Hansen

Post Doctoral Fellows
Ben Wheaton

Recent Publications
Wang, X., Sharp, A.R. and Miller R.D. 2012. Early postnantal B cell ontogeny and antibody repertoire maturation in the opossum, Monodelphis domestica. PLoS ONE 7(9):e45931.

Parra, Z. E., Mitchell, K., Dalloul, R. A. and Miller, R. D. 2012. A second TCRdelta locus in Galliformes uses antibody-like V domains: insight into the evolution of TCRdelta and TCRmu genes in tetrapods. Journal of Immunology 188:3912-3919.

Parra, Z. E., Lillie, M., and Miller, R. D. 2012. A model for the evolution of the mammalian T cell receptor alpha/delta and mu loci based on evidence from the duckbill platypus. Molecular Biology and Evolution 29:3205-3214.

Parra, Z.E. and Miller, R. D. 2012. Comparative analysis of the chicken TCRalpha/delta locus. Immunogenetics 64:641-645.

Wang, X., Parra, Z. E., and Miller R. D. 2012. A VpreB3 homologue from a marsupial, the gray short-tailed opossum, Monodelphis domestica. Immunogenetics 64:647-652

Wang, X. and Miller R. D. 2012. Recombination, transcription and diversity of a partially germ-line joined VH in a mammal. Immunogenetics DOI: 10.1007/s00251-012-0627-z

Miller, R. D. 2012. Phylogeny of the mucosal immune system. In Principles of Mucosal Immunology. Eds. P. Smith, T. T. MacDonald, and R. Blumberg. Garland Publishing, pp 19-26.

Wong, E.S.W., Papenfuss, A.T., Heger, A., Hsu, A.L., Ponting, C.P., Miller, R.D., Fenelon, J.C., Renfree, M.B., Gibbs, R.A., and Belov, K. 2011. Transcriptomic analysis supports similar functional roles for the two thymuses of the tammar wallaby. BMC Genomics 12:420.

Wang, X., Parra, Z. E. and Miller R. D. 2011. Platypus TCRμ provides insight into the origins and evolution of a uniquely mammalian TCR locus. Journal of Immunology 187:5246-5254.

Parra, Z. E., Ohta, Y., Criscitiello, M. F., Flajnik, M. F., and Miller R. D. 2010. The dynamic TCRδ: TCRδ chains in the amphibian Xenopus tropicalis utilize antibody-like V genes. European Journal of Immunology 40:2319-2329.

Miller, R. D. 2010. Those other mammals: The immunoglobulins and T cell receptors of marsupials and monotremes. Seminars in Immunology 22:3-9.

Wang, X., Olp, J. J., and Miller R. D. 2009. On the genomics of immunoglobulins in the gray, short-tailed opossum Monodelphis domestica. Immunogenetics 61:581–596.

Baker, M. L., Melman, S. D., Huntley, J. and Miller, R. D. 2009. Evolution of the opossum MHC: Evidence for diverse alternative splice patterns and low polymorphism among class I genes. Immunology 128:418-431.

Parra, Z. E., Baker, M. L., Lopez, A. M., Trujillo, J., Volpe, J. M. and Miller, R. D. 2009. TCRμ recombination and transcription relative to the conventional TCR during postnatal development in opossums. Journal of Immunology 182:154-163.

Parra, Z. E., Baker, M. L., Hathaway, J., Lopez, A. M., Trujillo, J., Sharp, A. and Miller, R. D. 2008. Comparative genomic analysis and evolution of the T cell receptor loci in the opossum Monodelphis domestica. BMC Genomics 9:111.

Parra, Z.E., Baker, M. L., Schwarz, R., Deakin, J. E., Lindblad-Toh K., and Miller, R.D. 2007. Discovery of a new T cell receptor in marsupials. Proceedings of the National Academy of Sciences USA 104:9776-9781.

Mikkelsen, T.S., Wakefield, M.J., Aken, B., Amemiya, C.T., Chang, J.L., Duke, S., Garber, M., Gentles, A.J., Goodstadt, L., Heger, A., Jurka, J., Kamal, M., Mauceli, E., Searle, S.M.J., Sharpe, T., Baker, M.L., Batzer, M.A., Benos, P.V., Belov, K., Clamp, M., Cook, A., Cuff, J., Das, R., Davidow, L., Deakin, J.E., Fazzari, M.J., Glass J.L., Grabherr, M., Greally, J.M., Gu, W., Hore, T.A., Huttley G.A., Jirtle, R.L., Koina, E., Lee J.T., Mahony, S., Marra, M.A., Miller, R.D., Nicholls, R.D., Oda, M., Papenfuss, A.T., Parra, Z.E., Pollock, D.D., Ray, D.A., Schein, J.E., Speed, T.P., Thompson, K., VandeBerg, J.L., Wade, C.M., Walker, Waters, P.D., J.A., Webber, C., Weidman, J.R., Xie, X., Zody, M.C., Broad Institute Genome Sequencing Platform, Broad Institute Whole Genome Assembly Team, Marshall Graves, J.A., Ponting, C.P., Breen, M., Samollow, P.B., Lander, E.S., and Lindblad-Toh, K.S. 2007. Genome of the marsupial Monodelphis domestica reveals lineage-specific innovation in coding sequences. Nature 447:167-178.

Baker, M. L. and Miller, R. D. 2007. Evolution of mammalian CD1: Marsupial CD1 is not orthologous to the eutherian isoforms and is a pseudogene in the opossum Monodelphis domestica. Immunology 121:113-121.

Baker, M. L., Indiviglio, S., Nyberg A. M., Rosenberg, G. H., Lindblad-Toh K., Miller, R. D., and Papenfuss, A. T. 2007. Analysis of a set of Australian northern brown bandicoot expressed sequence tags with comparison to the genome sequence of the South American grey short tailed opossum. BMC Genomics 8:50.